{
  "version": "https://jsonfeed.org/version/1.1",
  "title": "chem-bla-ics",
  "description": "Chemblaics (pronounced chem-bla-ics) is the science that uses open science and computers to solve problems in chemistry, biochemistry and related fields.",
  "home_page_url": "https://chem-bla-ics.linkedchemistry.info/",
  "feed_url": "https://chem-bla-ics.linkedchemistry.info/2025/01/26/niche-papers.json",
  "icon": "https://chem-bla-ics.linkedchemistry.info/assets/images/chem-bla-ics_logo.png",
  "language": "en",
  "authors": [
    {
      "name": "Egon Willighagen",
      "url": "https://orcid.org/0000-0001-7542-0286",
      "_orcid": "0000-0001-7542-0286"
    }
  ],
  "items": [

    {
      "id": "https://doi.org/10.59350/am3yq-9xx77",
      "url": "https://chem-bla-ics.linkedchemistry.info/2025/01/26/niche-papers.html",
      "title": "Niche papers and citation intentions",
      "content_html": "<p>I wish I could say I remember the first citation to one of my research articles. I do not. But I do remember\nthe excitement to see why someone was citing my research. What I do remember is that I got a comment around\nthe same time along the lines of this: <em>“why would anyone cite your article if they can download the results\nfor free?”</em> (about open science cheminformatics research). Other times. Indeed, I found out there are many reasons why people are citing and not citing\narticles. The above is one of them (still happens too often). But that’s also an intrinsic property of the\ncurrent publishing model: some papers get cited too much, others get cited too little.</p>\n\n<p><a href=\"https://scholar.social/@dingemansemark\">Mark Dingemanse</a> wrote up a post <em><a href=\"https://doi.org/10.59350/m6erd-7px95\">[i]n praise of niche papers</a></em>,\nsuggesting people to highlight papers that are not cited enough (as proxy for not getting enough attention).\nThey write:</p>\n\n<blockquote>\n  <p>Let’s define niche papers informally as work to be proud of even if it managed to remain a bit obscure;\ngood work that would deserve more readers. Niche papers may not contain the most flashy results. They\nmay not appear in the most glamourous venues. They may be book chapters. They don’t easily gather\ndrive-by citations.</p>\n</blockquote>\n\n<h2 id=\"why-i-found-this-post-interesting\">Why I found this post interesting</h2>\n\n<p>Before I move on to highlighting niche papers (from our group and from others), I want to ponder\na bit more about the rest. The first I learned is that the citation count to articles is a bad measure\nfor the impact (<a href=\"https://chem-bla-ics.linkedchemistry.info/2006/11/07/when-is-open-source-chemoinformatics.html\">2006 pondering</a>):\narticles using your work may get more citations than your own article. For example, the first paper\n(doi:<a href=\"https://doi.org/10.1021/CI025584Y\">10.1021/CI025584Y</a>) about the open science cheminformatics\nabout the <a href=\"https://cdk.github.io\">Chemistry Development Kit</a> (CDK) was originally cited less than\nthe paper about the BRENDA enzyme database (doi:<a href=\"https://doi.org/10.1093/NAR/GKH081\">10.1093/NAR/GKH081</a>)\nusing the CDK for fingerprint calculations (to compare and search enzyme substrates), and later much\nless than MZmine (doi:<a href=\"https://doi.org/10.1186/1471-2105-11-395\">10.1186/1471-2105-11-395</a>)\n(see <a href=\"https://scholia.toolforge.org/works/Q27061829,Q27136473,Q24599948\">this Scholia page</a>):</p>\n\n<p><img src=\"/assets/images/cdk_citations.png\" alt=\"\" /></p>\n\n<p>I think we should with limiting ourselves to papers and book chapters. We must extend out notion of research output,\nanyway, starting with data and software. This is part of defining what niche is, imo.</p>\n\n<p>Second reason why I liked Mark’s post is the <em>drive-by citations</em>, which he references to\n<a href=\"https://scatter.wordpress.com/2009/04/30/drive-by-citations/\">a 2009 post by andrewperrin</a> which defined\nsuch a citations as</p>\n\n<blockquote>\n  <p>references to a work that make a very quick appearance, extract a very small, specific point from the work,\nand move on without really considering the existence or depth of connection between the student’s work and\nthe cited work.</p>\n</blockquote>\n\n<p>This is someone I noted too when analyzing citations to the aforementioned CDK paper. Particularly in the\nearly days, it was cited a lot in a similar way: it was not using the CDK, but ascribed some authority\nto the paper in a <em>very quick appearance, without really considering the cited work</em>. The\n<a href=\"https://purl.org/spar/cito\">Citation Typing Ontology</a> (CiTO, doi:<a href=\"https://doi.org/10.1186/2041-1480-1-s1-s6\">10.1186/2041-1480-1-s1-s6</a>)\nhas <em>cito:citesAsAuthority</em> for that (not exactly the same thing,\nand maybe CiTO should have <em>cito:driveByCitation</em> too). And they happen a lot, and in the past I have\nguestimated them to make up 20-35% of the citations to an article, and I postulate that\nhigh-journal-impact-factor journals amass a higher ratio than specialistic (niche?) journals.</p>\n\n<p>With FAIR citations (see <a href=\"https://chem-bla-ics.linkedchemistry.info/2024/12/30/fair-blog-to-blog-citations.html\">this post</a>)\nwe can visualize that ratio, here in <a href=\"https://scholia.toolforge.org/work/Q27061829#cito-incoming\">this Scholia page</a>:</p>\n\n<p><img src=\"/assets/images/cdk_citations_why.png\" alt=\"\" /></p>\n\n<p>It is also obvious that the first CDK paper introduced a new method. But the pattern is not\nlimited to this paper, and with <a href=\"https://scholia.toolforge.org/cito/#article-counts\">just over 2000 citation intentions</a>,\nwe start of get some idea of this pattern:</p>\n\n<p><img src=\"/assets/images/citations_why.png\" alt=\"\" /></p>\n\n<h2 id=\"my-contributed-niche-papers\">My contributed Niche Papers</h2>\n\n<p>That brings me to a first neglected paper, David Shotton’s original conference proceedings <em>CiTO, the Citation Typing Ontology</em>\n(doi:<a href=\"https://doi.org/10.1186/2041-1480-1-S1-S6\">10.1186/2041-1480-1-S1-S6</a>), another paper where citing articles\nare more cited than the original:</p>\n\n<p><img src=\"/assets/images/cito_openalex.png\" alt=\"\" /></p>\n\n<p>A second example is cited even less (only <a href=\"https://openalex.org/works?page=1&amp;filter=cites%3Aw2103581950\">36 times</a>\naccording to OpenAlex), but a wonderful early example of machine learning of a massive amount of data:\n<em>Genome‐Scale Classification of Metabolic Reactions: A Chemoinformatics Approach</em> (doi:<a href=\"https://doi.org/10.1002/anie.200503833\">10.1002/anie.200503833</a>) by\nDiogo Latino and João Aires‐de‐Sousa. My <a href=\"https://chem-bla-ics.linkedchemistry.info/2006/04/04/mining-kegg-pathway-database-with-self.html\">2006 blog post</a>\nabout their article did not make a difference. And this is remarkable if you look at home many articles\nare <a href=\"https://scholar.google.com/scholar?hl=en&amp;as_sdt=0,5&amp;as_ylo=2021&amp;q=enzyme+reaction+classification+with+machine+learning\">published now yearly in similar efforts</a>.</p>\n\n<p>From our group, I think the impact of <a href=\"https://scholar.google.com/citations?view_op=list_works&amp;hl=en&amp;hl=en&amp;user=bJYJJVMAAAAJ\">Ryan Miller</a>’s\n<em>Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions</em>\n(doi:<a href=\"https://doi.org/10.1371/journal.pone.0263057\">10.1371/journal.pone.0263057</a> is not fully appreciated yet. This\npaper describes and validates work by Ryan, Martina Kutmon, Answesha Bohler, and Andra Waagmeester on modelling biological\ninteraction in a FAIR way. It builds on earlier work, like the <a href=\"https://rdf.wikipathways.org/\">WikiPathways RDF</a>\nwork by Andra (doi:<a href=\"https://doi.org/10.1371/JOURNAL.PCBI.1004989\">10.1371/journal.pcbi.1004989</a>),\nbut zooms in on the interactions and develops method to assess the quality of the FAIR modelling\nof them. This provides us with a method to evaluate later analyses where these interactions are used.</p>\n\n<p>A second paper from our group which I expected to get more attention is a paper by <a href=\"https://scholar.google.com/citations?hl=en&amp;user=8ZmXyZcAAAAJ\">Ammar</a>\n(doi:<a href=\"https://doi.org/10.1186/s13321-023-00701-3\">10.1186/s13321-023-00701-3</a>) where he looked\ninto personalized binding affinities. That is, drugs may bind better to their targets for some\npeople than for other (and therefore work better for some people than for other), and his analysis\nsuggests they impact can be significant. We will learn in time.</p>\n\n<h4>References</h4>\n<div class=\"csl-bib-body\">\n    <div class=\"csl-entry\">Ammar, A., Cavill, R., Evelo, C., &#38; Willighagen, E. (2023). PSnpBind-ML: predicting the effect of binding site mutations on protein-ligand binding affinity. <i>Journal of Cheminformatics</i>, <i>15</i>(1). https://doi.org/10.1186/s13321-023-00701-3 <a href=\"https://doi.org/10.1186/S13321-023-00701-3\">CrossRef</a> <a href=\"https://qlever.scholia.wiki/doi/10.1186/S13321-023-00701-3\">Scholia</a></div>\n    <div class=\"csl-entry\">Dingemanse, M. (2025). In praise of niche papers. In <i>Front Matter</i>. Front Matter. https://doi.org/10.59350/m6erd-7px95 <a href=\"https://doi.org/10.59350/m6erd-7px95\">CrossRef</a> <a href=\"https://qlever.scholia.wiki/doi/10.59350/m6erd-7px95\">Scholia</a></div>\n    <div class=\"csl-entry\">Latino, D. A. R. S., &#38; Aires‐de‐Sousa, J. (2006). Genome‐Scale Classification of Metabolic Reactions: A Chemoinformatics Approach. <i>Angewandte Chemie International Edition</i>, <i>45</i>(13), 2066–2069. https://doi.org/10.1002/anie.200503833 <a href=\"https://doi.org/10.1002/anie.200503833\">CrossRef</a> <a href=\"https://qlever.scholia.wiki/doi/10.1002/anie.200503833\">Scholia</a></div>\n    <div class=\"csl-entry\">Miller, R. A., Kutmon, M., Bohler, A., Waagmeester, A., Evelo, C. T., &#38; Willighagen, E. L. (2022). Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions. <i>PLOS ONE</i>, <i>17</i>(4), e0263057. https://doi.org/10.1371/journal.pone.0263057 <a href=\"https://doi.org/10.1371/JOURNAL.PONE.0263057\">CrossRef</a> <a href=\"https://qlever.scholia.wiki/doi/10.1371/JOURNAL.PONE.0263057\">Scholia</a></div>\n    <div class=\"csl-entry\">Pluskal, T., Castillo, S., Villar-Briones, A., &#38; Orešič, M. (2010). MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. <i>BMC Bioinformatics</i>, <i>11</i>(1). https://doi.org/10.1186/1471-2105-11-395 <a href=\"https://doi.org/10.1186/1471-2105-11-395\">CrossRef</a> <a href=\"https://qlever.scholia.wiki/doi/10.1186/1471-2105-11-395\">Scholia</a></div>\n    <div class=\"csl-entry\">Schomburg, I. (2004). BRENDA, the enzyme database: updates and major new developments. <i>Nucleic Acids Research</i>, <i>32</i>(90001), 431D – 433. https://doi.org/10.1093/nar/gkh081 <a href=\"https://doi.org/10.1093/NAR/GKH081\">CrossRef</a> <a href=\"https://qlever.scholia.wiki/doi/10.1093/NAR/GKH081\">Scholia</a></div>\n    <div class=\"csl-entry\">Shotton, D. (2010). CiTO, the Citation Typing Ontology. <i>Journal of Biomedical Semantics</i>, <i>1</i>(S1). https://doi.org/10.1186/2041-1480-1-s1-s6 <a href=\"https://doi.org/10.1186/2041-1480-1-S1-S6\">CrossRef</a> <a href=\"https://qlever.scholia.wiki/doi/10.1186/2041-1480-1-S1-S6\">Scholia</a></div>\n    <div class=\"csl-entry\">Steinbeck, C., Han, Y., Kuhn, S., Horlacher, O., Luttmann, E., &#38; Willighagen, E. (2003). The Chemistry Development Kit (CDK):  An Open-Source Java Library for Chemo- and Bioinformatics. <i>Journal of Chemical Information and Computer Sciences</i>, <i>43</i>(2), 493–500. https://doi.org/10.1021/ci025584y <a href=\"https://doi.org/10.1021/CI025584Y\">CrossRef</a> <a href=\"https://qlever.scholia.wiki/doi/10.1021/CI025584Y\">Scholia</a></div>\n    <div class=\"csl-entry\">Waagmeester, A., Kutmon, M., Riutta, A., Miller, R., Willighagen, E. L., Evelo, C. T., &#38; Pico, A. R. (2016). Using the Semantic Web for Rapid Integration of WikiPathways with Other Biological Online Data Resources. <i>PLOS Computational Biology</i>, <i>12</i>(6), e1004989. https://doi.org/10.1371/journal.pcbi.1004989 <a href=\"https://doi.org/10.1371/JOURNAL.PCBI.1004989\">CrossRef</a> <a href=\"https://qlever.scholia.wiki/doi/10.1371/JOURNAL.PCBI.1004989\">Scholia</a></div>\n  </div>",
      "summary": "I wish I could say I remember the first citation to one of my research articles. I do not. But I do remember the excitement to see why someone was citing my research. What I do remember is that I got a comment around the same time along the lines of this: “why would anyone cite your article if they can download the results for free?” (about open science cheminformatics research). Other times. Indeed, I found out there are many reasons why people are citing and not citing articles. The above is one of them (still happens too often). But that’s also an intrinsic property of the current publishing model: some papers get cited too much, others get cited too little.",
      "image": "https://chem-bla-ics.linkedchemistry.infoassets/images/cdk_citations.png",
      "date_published": "2025-01-26T00:00:00+00:00",
      "date_modified": "2025-01-26T00:00:00+00:00",
      "tags": ["publishing"],
      "_references": [
        
          
          
            { "url": "https://doi.org/10.59350/m6erd-7px95", "doi": "10.59350/m6erd-7px95"
             }
            ,
          
        
          
          
            { "url": "https://doi.org/10.1021/CI025584Y", "doi": "10.1021/CI025584Y"
             }
            ,
          
        
          
          
            { "url": "https://doi.org/10.1186/1471-2105-11-395", "doi": "10.1186/1471-2105-11-395"
             }
            ,
          
        
          
          
            { "url": "https://doi.org/10.1093/NAR/GKH081", "doi": "10.1093/NAR/GKH081"
             }
            ,
          
        
          
          
            { "url": "https://doi.org/10.1002/anie.200503833", "doi": "10.1002/anie.200503833"
             }
            ,
          
        
          
          
            { "url": "https://doi.org/10.1186/2041-1480-1-S1-S6", "doi": "10.1186/2041-1480-1-S1-S6"
             }
            ,
          
        
          
          
            { "url": "https://doi.org/10.1371/JOURNAL.PONE.0263057", "doi": "10.1371/JOURNAL.PONE.0263057"
             }
            ,
          
        
          
          
            { "url": "https://doi.org/10.1371/JOURNAL.PCBI.1004989", "doi": "10.1371/JOURNAL.PCBI.1004989"
             }
            ,
          
        
          
          
            { "url": "https://doi.org/10.1186/S13321-023-00701-3", "doi": "10.1186/S13321-023-00701-3"
             }
            
          
        ],
      
      
      
      
      
      
        "authors": [ { "name": "Egon Willighagen", "url": "https://orcid.org/0000-0001-7542-0286" } ]
      
    }

  ]
}
