{
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  "title": "chem-bla-ics",
  "description": "Chemblaics (pronounced chem-bla-ics) is the science that uses open science and computers to solve problems in chemistry, biochemistry and related fields.",
  "home_page_url": "https://chem-bla-ics.linkedchemistry.info/",
  "feed_url": "https://chem-bla-ics.linkedchemistry.info/2007/03/14/what-is-dapagliflozin.json",
  "icon": "https://chem-bla-ics.linkedchemistry.info/assets/images/chem-bla-ics_logo.png",
  "language": "en",
  "authors": [
    {
      "name": "Egon Willighagen",
      "url": "https://orcid.org/0000-0001-7542-0286",
      "_orcid": "0000-0001-7542-0286"
    }
  ],
  "items": [

    {
      "id": "https://doi.org/10.59350/3et2a-pkv75",
      "url": "https://chem-bla-ics.linkedchemistry.info/2007/03/14/what-is-dapagliflozin.html",
      "title": "What is dapagliflozin?",
      "content_html": "<p><a href=\"http://www.qdinformation.com/qdisblog\">QDIS</a> blogged about <a href=\"http://www.qdinformation.com/qdisblog/2007/01/11/bristol-myers-and-astrazeneca-in-1-billion-drug-pact/\">Bristol-Myers and AstraZeneca teaming up for a new drug called\ndapagliflozin</a>. Now,\ndapagliflozin is, this week, the most used search keyword in <a href=\"http://www.google.com/\">Google</a>, leading to\n<a href=\"http://wiki.cubic.uni-koeln.de/cb/\">Chemical blogspace</a>.</p>\n\n<p>I wondered what the chemical structure of this compound is. The <a href=\"http://www.astrazeneca.com/\">AstraZeneca</a> and\n<a href=\"http://www.bms.com/\">Bristol-Myers Squibb</a> websites don’t say. Since everything in pharma is patented I went to the US\npatent database and a search for <em>DPP-4 AND inhibitor</em> found the patents <a href=\"http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&amp;Sect2=HITOFF&amp;p=1&amp;u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&amp;r=1&amp;f=G&amp;l=50&amp;co1=AND&amp;d=PTXT&amp;s1=DPP-4&amp;s2=inhibitor&amp;OS=DPP-4+AND+inhibitor&amp;RS=DPP-4+AND+inhibitor\">6,995,183</a>\nand <a href=\"http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&amp;Sect2=HITOFF&amp;p=1&amp;u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&amp;r=2&amp;f=G&amp;l=50&amp;co1=AND&amp;d=PTXT&amp;s1=DPP-4&amp;s2=inhibitor&amp;OS=DPP-4+AND+inhibitor&amp;RS=DPP-4+AND+inhibitor\">6,995,180</a>.\nBut that does not help me either.</p>\n\n<p>Does anyone know the chemical structure of this compound? Just the InChI would be fine…</p>",
      "summary": "QDIS blogged about Bristol-Myers and AstraZeneca teaming up for a new drug called dapagliflozin. Now, dapagliflozin is, this week, the most used search keyword in Google, leading to Chemical blogspace.",
      
      "date_published": "2007-03-14T00:00:00+00:00",
      "date_modified": "2025-02-15T00:00:00+00:00",
      
      
      
      
      
      
      
        "authors": [ { "name": "Egon Willighagen", "url": "https://orcid.org/0000-0001-7542-0286" } ]
      
    }

  ]
}
